Tgfbr3^tm1.1Hlin
Targeted Allele Detail

Summary

• Symbol: Tgfbr3^tm1.1Hlin
• Name: transforming growth factor, beta receptor III; targeted mutation 1.1, Herbert Y Lin
• MGI ID: MGI:6220924
• Synonyms: Tgfbr3^fx
• Gene: Tgfbr3 Location: Chr5:107254436-107437495 bp, - strand Genetic Position: Chr5, 51.9 cM
• Alliance: Tgfbr3^tm1.1Hlin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266352
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. A floxed neomycin resistance cassette was inserted downstream of exon 2. Cre-mediated recombination removed the selection cassette and left exon 2 floxed. (J:266352)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgfbr3 Mutation: 52 strains or lines available

References

• Original: J:266352 Li Y, et al., Betaglycan (TGFBR3) functions as an inhibin A, but not inhibin B, co-receptor in pituitary gonadotrope cells in mice. Endocrinology. 2018 Oct 25
• All: 4 reference(s)