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Rsph6aem2Osb
Endonuclease-mediated Allele Detail
Summary
Symbol: Rsph6aem2Osb
Name: radial spoke head 6 homolog A (Chlamydomonas); endonuclease-mediated mutation 2, Osaka University
MGI ID: MGI:6241362
Synonyms: Rsph6aLD
Gene: Rsph6a  Location: Chr7:18788615-18808372 bp, + strand  Genetic Position: Chr7, 9.46 cM, cytoband A2
Alliance: Rsph6aem2Osb page
Mutation
origin
Strain of Origin:  (C57BL/6NJcl x DBA/2NJcl)F2
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR/cas9 mediated recombination created a 12,068 bp deletion spanning from exon 1 to exon 4. This deletion removes amino acids 122-542 of the long isoform (variant 1) and amino acids 122-289 of the short isoform (variant 2). Western blot analysis confirmed the absence of expression in homozygous mice. (J:266136)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Rsph6a Mutation:  36 strains or lines available
References
Original:  J:266136 Abbasi F, et al., RSPH6A is required for sperm flagellum formation and male fertility in mice. J Cell Sci. 2018 Oct 11;131(19):jcs221648
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory