Hectd3^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Hectd3^tm1Lex
• Name: HECT domain E3 ubiquitin protein ligase 3; targeted mutation 1, Lexicon Genomics
• MGI ID: MGI:6256423
• Gene: Hectd3 Location: Chr4:116852514-116862474 bp, + strand Genetic Position: Chr4, 53.41 cM
• Alliance: Hectd3^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266602
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A puromycin resistance selection cassette replaced coding exon 10 through 17, deleting the functional HECT domain. (J:266602)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hectd3 Mutation: 42 strains or lines available

References

• Original: J:266602 Li F, et al., HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. J Clin Invest. 2018 Aug 31;128(9):4148-4162
• All: 2 reference(s)