Tg(Myh6-Tpm1*D230N)HJcf
Transgene Detail

Summary

• Symbol: Tg(Myh6-Tpm1*D230N)HJcf
• Name: transgene insertion H, Jil C Tardiff
• MGI ID: MGI:6256754
• Synonyms: D230N-high
• Transgene: Tg(Myh6-Tpm1*D230N)HJcf Location: unknown
• Alliance: Tg(Myh6-Tpm1*D230N)HJcf page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Tpm1*D230N)HJcf expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Tpm1

• Mutation details: The alpha-tropoyosin containing a substitution of an aspartic acid for asparagine at residue 230 (D230N) is under the control of the cardiac specific rat alpha-myosin heavy chain promoter. This is the high-expressing line that expresses about 69% of the total Tpm1 as the mutant transgenic form. (J:243724)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:243724 Lynn ML, et al., The structural basis of alpha-tropomyosin linked (Asp230Asn) familial dilated cardiomyopathy. J Mol Cell Cardiol. 2017 Jul;108:127-137
• All: 1 reference(s)