Tg(Pthlh-cre/ERT2)909Nono
Transgene Detail

Summary

• Symbol: Tg(Pthlh-cre/ERT2)909Nono
• Name: transgene insertion 909, Noriaki Ono
• MGI ID: MGI:6257033
• Synonyms: Pthrp-creER
• Transgene: Tg(Pthlh-cre/ERT2)909Nono Location: unknown
• Alliance: Tg(Pthlh-cre/ERT2)909Nono page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Pthlh-cre/ERT2)909Nono expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pthlh (MGI:97800)

• Mutation details: A bacterial artificial chromosome (BAC) library (CHORI) was used to obtain a BAC (#RP23-27F7) containing the entire mouse parathyroid hormone-like peptide (Pthlh) gene. This BAC was modified to replace the native start codon of the Pthlh gene with a cre/ERT2 fusion gene (Cre recombinase fused to a human estrogen receptor ligand-binding domain), followed by an SV40 polyadenylation sequence. (J:266751)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pthlh (mouse) Summary of all recombinase alleles driven by Pthlh. Comparative matrix view of recombinase activities Alliance mouse Pthlh gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:266751 Mizuhashi K, et al., Resting zone of the growth plate houses a unique class of skeletal stem cells. Nature. 2018 Nov;563(7730):254-258
• All: 5 reference(s)