Uqcr10^em1(IMPC)Bay
Endonuclease-mediated Allele Detail

Summary

• Symbol: Uqcr10^em1(IMPC)Bay
• Name: ubiquinol-cytochrome c reductase, complex III subunit X; endonuclease-mediated mutation 1, Baylor College of Medicine
• MGI ID: MGI:6257426
• Synonyms: Uqcr10^-
• Gene: Uqcr10 Location: Chr11:4651973-4654342 bp, - strand Genetic Position: Chr11, 2.96 cM
• Alliance: Uqcr10^em1(IMPC)Bay page
• IMPC: Uqcr10 gene page

Uqcr10^em1(IMPC)Bay/Uqcr10^em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos show severe developmental delay presenting as a small egg cylinder and poorly organized extraembryonic tissues.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6N
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele from IMPC was generated at Bayor College of Medicine by injecting CAS9 RNA, 2 guide sequences GCACGGTCTCAACTACCAAGCGG, CCGAACTCGCGCCACTGCGCTTG, and a donor oligo, which resulted in a Conditional Ready allele. (J:265051)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Uqcr10 Mutation: 17 strains or lines available

References

• Original: J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023
• All: 2 reference(s)