Itm2c^em2(IMPC)Tcp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Itm2c^em2(IMPC)Tcp
• Name: integral membrane protein 2C; endonuclease-mediated mutation 2, The Centre for Phenogenomics
• MGI ID: MGI:6257738
• Gene: Itm2c Location: Chr1:85822231-85836419 bp, + strand Genetic Position: Chr1, 43.94 cM
• Alliance: Itm2c^em2(IMPC)Tcp page
• IMPC: Itm2c gene page

Mutation origin

• Strain of Origin: C57BL/6NCrl
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele produced from project TCPR0313 at TCP by injecting Cas9 mRNA and one guide RNA with the spacer sequence CCTTTCCGGGAGCGGTGGCG. This resulted in a 15-bp deletion from Chr1:85903021 to 85903035_insT (GRCm38) in ENSMUSE00000330277. This mutation is predicted to cause a frameshift with amino acid changes after residue 48 and early truncation 40 amino acids later (p.R48Efs*42). (GRCm38). (J:265051)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Itm2c Mutation: 19 strains or lines available

References

• Original: J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023
• All: 3 reference(s)