Tg(KRT5-Terf2)PNBlas
Transgene Detail

Summary

• Symbol: Tg(KRT5-Terf2)PNBlas
• Name: transgene insertion PN, Maria A Blasco
• MGI ID: MGI:6258223
• Synonyms: PN K5-Terf2
• Transgene: Tg(KRT5-Terf2)PNBlas Location: unknown
• Alliance: Tg(KRT5-Terf2)PNBlas page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT5-Terf2)PNBlas expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Terf2 (MGI:1195972)

• Tg(KRT5-Terf2)PNBlas expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  cattle	KRT5 (281268)

• Mutation details: The full-length mouse Terf2 cDNA was placed under control of the 5' regulatory region of the bovine keratin K5 promoter, which targets TERF2 to basal cells and stem cells of the epidermis. Three transgenic lines were generated and analyzed (PM, PN and PO). In the PN line (males and females), the levels of Terf2 mRNA expression in tail and back skin were ~12 times greater than those in wild-type controls. (J:102653)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:102653 Munoz P, et al., XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer. Nat Genet. 2005 Oct;37(10):1063-71
• All: 1 reference(s)