Rai1^tm3Luo
Targeted Allele Detail

Summary

• Symbol: Rai1^tm3Luo
• Name: retinoic acid induced 1; targeted mutation 3, Liqun Luo
• MGI ID: MGI:6258448
• Synonyms: Rai1^STOP
• Gene: Rai1 Location: Chr11:59995839-60090023 bp, + strand Genetic Position: Chr11, 37.81 cM, cytoband B2
• Alliance: Rai1^tm3Luo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266251
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutation: Insertion
• A loxP-flanked neomycin-3xpolyA Stop cassette was introduced upstream of the ATG start codon. (J:266251)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rai1 Mutation: 73 strains or lines available

References

• Original: J:266251 Huang WH, et al., Early adolescent Rai1 reactivation reverses transcriptional and social interaction deficits in a mouse model of Smith-Magenis syndrome. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10744-10749
• All: 1 reference(s)