Faxc^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Faxc^em1(IMPC)J
• Name: failed axon connections homolog; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6258582
• Gene: Faxc Location: Chr4:21931329-21996839 bp, + strand Genetic Position: Chr4, 9.2 cM
• Alliance: Faxc^em1(IMPC)J page
• IMPC: Faxc gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences TAGAGGGCAACAATCCCACA and GTAAACCTAAAAGTACCACC, which resulted in a 490 bp deletion beginning at Chromosome 4 position 21,936,545 bp and ending after 21,937,034 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001283152 (exon 2) and 354 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 89 and early truncation 28 amino acids later. There is a 7 bp insertion [TTTTAAG] at the deletion site. (J:188991)
• Inheritance: Not Specified

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Faxc^em1(IMPC)J/Faxc^em1(IMPC)J	C57BL/6NJ-Faxc^em1(IMPC)J/Mmjax
ht2	Faxc^em1(IMPC)J/Faxc^+	C57BL/6NJ-Faxc^em1(IMPC)J/Mmjax

Phenotypes:

Affected Systems	hm1	ht2
show or hide all annotated terms Sex:
Source:	IMPC - JAX	IMPC - JAX
behavior/neurological		√
decreased locomotor activity		√
mortality/aging	√
preweaning lethality, complete penetrance	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Faxc Mutation: 23 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)