Slain2^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slain2^em1(IMPC)J
• Name: SLAIN motif family, member 2; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6258620
• Gene: Slain2 Location: Chr5:73071705-73136184 bp, + strand Genetic Position: Chr5, 38.44 cM
• Alliance: Slain2^em1(IMPC)J page
• IMPC: Slain2 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences AGTATAGGACTATAAAGTAG and TTGAGTGTGTATATTTAGGC, which resulted in a 287 bp deletion beginning at Chromosome 5 position 72,941,237 bp and ending after 72,941,523 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001058225 (exon 2) and 138 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 129 and early truncation 9 amino acids later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Slain2 Mutation: 29 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)