Crbn^tm1.1Ble
Targeted Allele Detail

Summary

• Symbol: Crbn^tm1.1Ble
• Name: cereblon; targeted mutation 1.1, Benjamin L Ebert
• MGI ID: MGI:6258757
• Synonyms: Crbn^I391V
• Gene: Crbn Location: Chr6:106757162-106777038 bp, - strand Genetic Position: Chr6, 49.24 cM, cytoband E2
• Alliance: Crbn^tm1.1Ble page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267091
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: The targeting vector contains an FRT- and loxP-flanked neomycin cassette inserted upstream of exon 11 followed by a point mutation substitution isoleucine for the corresponding human residue, valine (I391V) in exon 11. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:267091)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crbn Mutation: 33 strains or lines available

References

• Original: J:267091 Fink EC, et al., Crbn (I391V) is sufficient to confer in vivo sensitivity to thalidomide and its derivatives in mice. Blood. 2018 Oct 4;132(14):1535-1544
• All: 3 reference(s)