Crb1^em2Boc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Crb1^em2Boc
• Name: crumbs family member 1, photoreceptor morphogenesis associated; endonuclease-mediated mutation 2, Bo Chang
• MGI ID: MGI:6259426
• Gene: Crb1 Location: Chr1:139124794-139304838 bp, - strand Genetic Position: Chr1, 60.87 cM
• Alliance: Crb1^em2Boc page

Early-onset multifocal depigmented retinal lesions in Crb1^em2Boc/Crb1^em2Boc Jak3^m1J/Jak3^m1J mice on a C57BL/6J background (A, B) but normal retinas in Crb1^em2Boc/Crb1^em2Boc mice on a DBA/2J background (C,D).

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: B6.Cg-Crb1^rd8 Jak3^m1J/BocJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This TALEN-mediated mutation, generated in mice homozygous for the rd8 allele, is a 17 base pair intragenic deletion in exon 9 spanning nucleotides 3481-3497, which causes a frameshift with 7 amino acid substitutions before early termination. (J:265859)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Crb1 Mutation: 92 strains or lines available

References

• Original: J:265859 Chang B, et al., Spontaneous Posterior Segment Vascular Disease Phenotype of a Mouse Model, rnv3, Is Dependent on the Crb1rd8 Allele. Invest Ophthalmol Vis Sci. 2018 Oct 1;59(12):5127-5139
• All: 2 reference(s)