Tg(Alb-SREBF1_ic)#Jkot
Transgene Detail

Summary

• Symbol: Tg(Alb-SREBF1_ic)#Jkot
• Name: transgene insertion, Jorg Kotzka
• MGI ID: MGI:6259431
• Synonyms: alb-SREBP-1c
• Transgene: Tg(Alb-SREBF1_ic)#Jkot Location: unknown
• Alliance: Tg(Alb-SREBF1_ic)#Jkot page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Alb-SREBF1_ic)#Jkot expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SREBF1 (6720)

  Srebf1

  (MGI:107606)

  mature 1c isoform

• Mutation details: The mouse albumin enhancer and promoter drive the expression of a 5'-HA tagged N-terminal transcriptionally active domain (aa 2-436; SREBP-1c-NT) of human SREBF1 in the liver. Western blot analysis detected by the HA tag confirms liver specific expression. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:185313)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:185313 Knebel B, et al., Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass. PLoS One. 2012;7(2):e31812
• All: 4 reference(s)