Trim67^tm1.2Slgu
Targeted Allele Detail

Summary

• Symbol: Trim67^tm1.2Slgu
• Name: tripartite motif-containing 67; targeted mutation 1.2, Stephanie L Gupton
• MGI ID: MGI:6259600
• Gene: Trim67 Location: Chr8:125519831-125561452 bp, + strand Genetic Position: Chr8, 72.81 cM
• Alliance: Trim67^tm1.2Slgu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266702
• Parent Cell Line: PRX-B6-albino #1 (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J/J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted about 200 bp upstream of the ATG start site and an FRT flanked neo cassette and loxP site were inserted downstream of exon 1 via homologous recombination. Recombinase mediated recombination removed exon 1 and the neo cassette. Immunohistochemical analysis confirmed the absence of protein expression in brains from homozygous mice. (J:266702)

Expression

In Mice Carrying this Mutation:	22 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim67 Mutation: 25 strains or lines available

References

• Original: J:266702 Boyer NP, et al., Mammalian TRIM67 Functions in Brain Development and Behavior. eNeuro. 2018 May-Jun;5(3):ENEURO.0186-18.2018
• All: 4 reference(s)