Itm2c^em1Nutt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Itm2c^em1Nutt
• Name: integral membrane protein 2C; endonuclease-mediated mutation 1, Stephen L Nutt
• MGI ID: MGI:6260167
• Synonyms: Itm2c^-
• Gene: Itm2c Location: Chr1:85822231-85836419 bp, + strand Genetic Position: Chr1, 43.94 cM
• Alliance: Itm2c^em1Nutt page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intergenic deletion
• Mutation details: A null allele was generated using CRISPR/Cas9-mediated gene deletion. Guide RNAs were designed to target intronic sequences flanking exons 2 and 5, resulting in the deletion of the intervening exons. No mRNA transcripts were detected in lipopolysaccharide (LPS) stimulated B cell cultures from homozygous mutant mice. (J:265892)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itm2c Mutation: 19 strains or lines available

References

• Original: J:265892 Trezise S, et al., Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins. Int J Mol Sci. 2018 Jul 24;19(8):2161
• All: 1 reference(s)