Lcor^tm1.2Hko
Targeted Allele Detail

Summary

• Symbol: Lcor^tm1.2Hko
• Name: ligand dependent nuclear receptor corepressor; targeted mutation 1.2, Haruhiko Koseki
• MGI ID: MGI:6267011
• Gene: Lcor Location: Chr19:41471076-41574975 bp, + strand Genetic Position: Chr19, 34.97 cM
• Alliance: Lcor^tm1.2Hko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262237
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The two coding exons were floxed. Flp-mediated recombination removed the selection cassette inserted downstream of the second coding exon. Cre-mediated recombination removed the two coding exons. Expression of Lcor was not affected. (J:262237)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lcor Mutation: 20 strains or lines available

References

• Original: J:262237 Conway E, et al., A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities. Mol Cell. 2018 May 3;70(3):408-421.e8
• All: 1 reference(s)