Gpr108^tm1.1Brs
Targeted Allele Detail

Summary

• Symbol: Gpr108^tm1.1Brs
• Name: G protein-coupled receptor 108; targeted mutation 1.1, Brian Seed
• MGI ID: MGI:6267426
• Gene: Gpr108 Location: Chr17:57541635-57555446 bp, - strand Genetic Position: Chr17, 29.74 cM, cytoband E1.1
• Alliance: Gpr108^tm1.1Brs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266821
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An attB and attP-flanked neomycin resistance cassette replaced 17 exons and 2 kb upstream. R4 integrase expression removed the selection cassette. RT-PCR confirmed the absence of transcript expression in spleen and lungs. (J:266821)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gpr108 Mutation: 26 strains or lines available

References

• Original: J:266821 Dong D, et al., GPR108, an NF-kappaB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses. PLoS One. 2018;13(10):e0205303
• All: 1 reference(s)