Sbno1^tm1.1Hssk
Targeted Allele Detail

Summary

• Symbol: Sbno1^tm1.1Hssk
• Name: strawberry notch 1; targeted mutation 1.1, Hiroshi Sasaki
• MGI ID: MGI:6267489
• Synonyms: Sbno1^delta
• Gene: Sbno1 Location: Chr5:124506765-124564059 bp, - strand Genetic Position: Chr5, 63.54 cM
• Alliance: Sbno1^tm1.1Hssk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266780
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 7. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 7. Cre-mediated recombination removed exon 7 and the selection cassette. (J:266780)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sbno1 Mutation: 87 strains or lines available

References

• Original: J:266780 Watanabe Y, et al., Notch and Hippo signaling converge on Strawberry Notch 1 (Sbno1) to synergistically activate Cdx2 during specification of the trophectoderm. Sci Rep. 2017 Apr 12;7:46135
• All: 1 reference(s)