Tbx21^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tbx21^m1Btlr
• Name: T-box 21; mutation 1, Bruce Beutler
• MGI ID: MGI:6268347
• Synonyms: plateau
• Gene: Tbx21 Location: Chr11:96988897-97006157 bp, - strand Genetic Position: Chr11, 60.95 cM, cytoband D
• Alliance: Tbx21^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced G to A transition at base pair 97,101,478 (v38) on chromosome 11, or base pair 13,854 in the GenBank genomic region NC_000077 within the donor splice site of intron 3. The effect of the mutation at the cDNA and protein levels has not been examined, but the mutation is predicted to result in skipping of the 122-nucleotide exon 3 (out of 6 total exons), resulting in a frame-shifted protein product beginning after amino acid 214 of the protein and premature termination after the inclusion of 20 aberrant amino acids. (J:267478)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbx21 Mutation: 39 strains or lines available

References

• Original: J:267478 Zhong X, et al., Mutagenetix entry for plateau. MGI Direct Data Submission. 2018
• All: 1 reference(s)