Ighe^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Ighe^M1Btlr
• Name: Immunoglobulin heavy constant epsilon; mutation 1, Bruce Beutler
• MGI ID: MGI:6268355
• Synonyms: Allegra
• Gene: Ighe Location: Chr12:113232883-113236868 bp, - strand Genetic Position: Chr12, 62.1 cM
• Alliance: Ighe^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced C to T transition at base pair 113,271,374 (v38) on chromosome 12, or base pair 1,875 in the GenBank genomic region NC_000078 encoding Ighe. The mutation corresponds to residue 1,167 in the cDNA sequence ENSMUST00000137336.2 within exon 4 of 4 total exons. The mutation results in substitution of glutamine (Q) to a premature stop codon (Q389*) in the Ighe protein. (J:267480)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ighe Mutation: 26 strains or lines available

References

• Original: J:267480 Yue T, et al., Mutagenetix entry for Allegra. MGI Direct Data Submission. 2018
• All: 1 reference(s)