Ptprc^m7Btlr
Chemically induced Allele Detail

Summary

• Symbol: Ptprc^m7Btlr
• Name: protein tyrosine phosphatase receptor type C; mutation 7, Bruce Beutler
• MGI ID: MGI:6268383
• Synonyms: jirisan
• Gene: Ptprc Location: Chr1:137990599-138103446 bp, - strand Genetic Position: Chr1, 60.73 cM
• Alliance: Ptprc^m7Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced G to T transversion at base pair 138,113,678 (v38) on chromosome 1, or base pair 62,079 in the GenBank genomic region NC_000067 encoding Ptprc. The mutation corresponds to residue 751 in the mRNA sequence NM_001111316 within exon 9 of 33 total exons, residue 432 in the mRNA sequence NM_011210 within exon 6 of 30 total exons, and residue 360 in the mRNA sequence NM_001268286 within exon 5 of 29 total exons. The mutation results in substitution of glutamic acid 238 for a premature stop codon (E238*) in variant 1 of the CD45 protein, a E99* substitution in variant 2, and a E75* substitution in variant 3. (J:267486)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprc Mutation: 189 strains or lines available

References

• Original: J:267486 Choi JH, et al., Mutagenetix entry for jirisan. MGI Direct Data Submission. 2018
• All: 1 reference(s)