Myo1d^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Myo1d^m2Btlr
• Name: myosin ID; mutation 2, Bruce Beutler
• MGI ID: MGI:6268406
• Synonyms: Myo1d^wpr, whisper
• Gene: Myo1d Location: Chr11:80372952-80670851 bp, - strand Genetic Position: Chr11, 47.95 cM
• Alliance: Myo1d^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to C transition at base pair 80,484,332 (v38) on chromosome 11 corresponding to base pair 295,724 in the GenBank genomic region NC_000077 encoding Myo1d. The mutation corresponds to residue 3,148 in the mRNA sequence NM_177390 within exon 22 of 22 total exons. The mutation results in a leucine (L) to proline (P) substitution at position 972 (L972P) in the Myo1d protein. (J:267525)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myo1d Mutation: 61 strains or lines available

References

• Original: J:267525 McAlpine W, et al., The class I myosin MYO1D binds to lipid and protects against colitis. Dis Model Mech. 2018 Sep 27;11(9):dmm035923
• All: 1 reference(s)