Myo1d^em1Btlr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Myo1d^em1Btlr
• Name: myosin ID; endonuclease-mediated mutation 1, Bruce Beutler
• MGI ID: MGI:6268688
• Synonyms: Myo1d^96ins
• Gene: Myo1d Location: Chr11:80372952-80670851 bp, - strand Genetic Position: Chr11, 47.95 cM
• Alliance: Myo1d^em1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR-targeting resulted in a 96 bp insertion consisting of multiple duplication events from exon 22 encoding 32 amino acids (TEKKCTVSVETRLNQPQPDFTKTRLNQPQPDF) inserted between residues 968 and 969. (J:267525)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myo1d Mutation: 61 strains or lines available

References

• Original: J:267525 McAlpine W, et al., The class I myosin MYO1D binds to lipid and protects against colitis. Dis Model Mech. 2018 Sep 27;11(9):dmm035923
• All: 1 reference(s)