Cr2^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Cr2^M1Btlr
• Name: complement receptor 2; mutation 1, Bruce Beutler
• MGI ID: MGI:6268702
• Synonyms: Pillar
• Gene: Cr2 Location: Chr1:194819119-194859024 bp, - strand Genetic Position: Chr1, 98.44 cM
• Alliance: Cr2^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to A transversion at base pair 195,155,888 (v38) on chromosome 1, or base pair 21,303 in the GenBank genomic region NC_000067 encoding Cr2. The mutation corresponds to residue 2,244 in the mRNA sequence NM_007758 within exon 12 of 19 total exons. The mutation results in substitution of cysteine 713 to a premature stop codon (C713*) in the CR2 protein. (J:267527)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cr2 Mutation: 84 strains or lines available

References

• Original: J:267527 Choi JH, et al., Mutagenetix entry for Pillar. MGI Direct Data Submission. 2018
• All: 1 reference(s)