Irs1^m1Btlr
Spontaneous Allele Detail

Summary

• Symbol: Irs1^m1Btlr
• Name: insulin receptor substrate 1; mutation 1, Bruce Beutler
• MGI ID: MGI:6268718
• Synonyms: runt
• Gene: Irs1 Location: Chr1:82210822-82269137 bp, - strand Genetic Position: Chr1, 42.0 cM, cytoband C5
• Alliance: Irs1^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Spontaneous (Not Specified)
• Mutation: Intragenic deletion
• Mutation details: ENU-induced 23 bp deletion in exon 1 (of 2 total exons) that causes a frameshift. The mutation is predicted to result in the addition of 5 aberrant amino acids after aa913 followed by a premature stop codon. (J:267531)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irs1 Mutation: 52 strains or lines available

References

• Original: J:267531 Turer E, et al., Mutagenetix entry for runt. MGI Direct Data Submission. 2018
• All: 1 reference(s)