Irs1^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Irs1^m2Btlr
• Name: insulin receptor substrate 1; mutation 2, Bruce Beutler
• MGI ID: MGI:6268722
• Synonyms: runt2
• Gene: Irs1 Location: Chr1:82210822-82269137 bp, - strand Genetic Position: Chr1, 42.0 cM, cytoband C5
• Alliance: Irs1^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to A transversion at base pair 82,286,967 (v38) on chromosome 1, or base pair 4,473 in the GenBank genomic region NC_000067 encoding Irs1. The mutation corresponds to residue 4,473 in the mRNA sequence NM_010570 within exon 1 of 2 total exons. The mutation results in substitution of leucine 1,176 to a premature stop codon (L1176*) in the IRS1 protein. (J:267532)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irs1 Mutation: 52 strains or lines available

References

• Original: J:267532 Turer E, et al., Mutagenetix entry for runt2. MGI Direct Data Submission. 2018
• All: 1 reference(s)