Irs2^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Irs2^M1Btlr
• Name: insulin receptor substrate 2; mutaiton 1, Bruce Beutler
• MGI ID: MGI:6268726
• Synonyms: Dum_dum
• Gene: Irs2 Location: Chr8:11034681-11058458 bp, - strand Genetic Position: Chr8, 5.35 cM
• Alliance: Irs2^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to G transversion at base pair 10,987,012 (v38) on chromosome 8, or base pair 21,420 in the GenBank genomic region NC_000074 encoding Irs2. The mutation corresponds to residue 3,964 in the mRNA sequence NM_001081212 within exon 2 of 2 total exons. The mutation results in substitution of the stop codon at position 1,322 to a glycine (*1322G) in the IRS2 protein. (J:267533)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irs2 Mutation: 37 strains or lines available

References

• Original: J:267533 Turer E, et al., Mutagenetix entry for Dum_dum. MGI Direct Data Submission. 2018
• All: 1 reference(s)