Insr^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Insr^m1Btlr
• Name: insulin receptor; mutation 1, Bruce Beutler
• MGI ID: MGI:6268730
• Synonyms: gummi_bear
• Gene: Insr Location: Chr8:3200922-3329649 bp, - strand Genetic Position: Chr8, 1.82 cM
• Alliance: Insr^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to C transition at base pair 3,161,770 (v38) on chromosome 8, or base pair 117,880 in the GenBank genomic region NC_000074 encoding Insr. The mutation corresponds to residue 3,739 in the mRNA sequence NM_010568 within exon 17 of 21 total exons. The mutation results in a serine (S) to proline (P) substitution at position 1,084 (S1084P) in the InsR protein. (J:267534)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Insr Mutation: 95 strains or lines available

References

• Original: J:267534 Turer E, et al., Mutagenetix entry for gummi_bear. MGI Direct Data Submission. 2018
• All: 1 reference(s)