Insr^M2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Insr^M2Btlr
• Name: insulin receptor; mutation 2, Bruce Beutler
• MGI ID: MGI:6268734
• Synonyms: Patently
• Gene: Insr Location: Chr8:3200922-3329649 bp, - strand Genetic Position: Chr8, 1.82 cM
• Alliance: Insr^M2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to C transition at base pair 3,159,475 (v38) on chromosome 8, or base pair 120,175 in the GenBank genomic region NC_000074 encoding Insr. The mutation corresponds to residue 4,096 in the mRNA sequence NM_010568 within exon 19 of 21 total exons. The mutation results in a phenylalanine to leucine substitution at position 1,203 (F1203L) in the INSR protein. (J:267535)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Insr Mutation: 95 strains or lines available

References

• Original: J:267535 Turer E, et al., Mutagenetix entry for Patently. MGI Direct Data Submission. 2018
• All: 1 reference(s)