Gsdmd^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Gsdmd^m1Btlr
• Name: gasdermin D; mutation 1, Bruce Beutler
• MGI ID: MGI:6268770
• Synonyms: gasder
• Gene: Gsdmd Location: Chr15:75734176-75739257 bp, + strand Genetic Position: Chr15, 35.0 cM, cytoband D3-E1
• Alliance: Gsdmd^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to C transition at base pair 75,864,357 (v38) on chromosome 15, or base pair 2,217 in the GenBank genomic region NC_000081 encoding Gsdmd. The mutation corresponds to residue 483 in the NM_026960 mRNA sequence in exon 3 of 11 total exons. The mutation results in a serine (S) to proline (P) substitution at residue 112 (S112P) in the GSDMD protein. (J:267555)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsdmd Mutation: 32 strains or lines available

References

• Original: J:267555 Shi H, et al., Mutagenetix entry for gasder. MGI Direct Data Submission. 2018
• All: 1 reference(s)