Il4ra^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Il4ra^M1Btlr
• Name: interleukin 4 receptor, alpha; mutation 1, Bruce Beutler
• MGI ID: MGI:6268775
• Synonyms: Lowe
• Gene: Il4ra Location: Chr7:125151443-125178646 bp, + strand Genetic Position: Chr7, 68.94 cM
• Alliance: Il4ra^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to C transition at base pair 125,567,221 (v38) on chromosome 7, or base pair 14,940 in the GenBank genomic region NC_000073. The mutation corresponds to residue 377 in the mRNA sequence NM_001008700 within exon 4 of 11 total exons. The mutation results in a tryptophan to arginine substitution at position 46 (W46R) in the IL-4R protein. (J:267558)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il4ra Mutation: 46 strains or lines available

References

• Original: J:267558 Yue T, et al., Mutagenetix entry for Lowe. MGI Direct Data Submission. 2018
• All: 1 reference(s)