Acsl6^tm1.1Jeme
Targeted Allele Detail

Summary

• Symbol: Acsl6^tm1.1Jeme
• Name: acyl-CoA synthetase long-chain family member 6; targeted mutation 1.1, Jessica M Ellis
• MGI ID: MGI:6268795
• Synonyms: Acsl6^-
• Gene: Acsl6 Location: Chr11:54194624-54255582 bp, + strand Genetic Position: Chr11, 32.13 cM
• Alliance: Acsl6^tm1.1Jeme page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267563
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were inserted into introns 1 and 2. Subsequent cre-mediated recombination deleted exon 2, creating a knockout allele. Western blots confirmed the absence of protein expression from the locus. (J:267563)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acsl6 Mutation: 46 strains or lines available

References

• Original: J:267563 Fernandez RF, et al., Acyl-CoA synthetase 6 enriches the neuroprotective omega-3 fatty acid DHA in the brain. Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):12525-12530
• All: 3 reference(s)