Hcn2^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Hcn2^m2Btlr
• Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 2; mutation 2, Bruce Beutler
• MGI ID: MGI:6269370
• Synonyms: curveball2
• Gene: Hcn2 Location: Chr10:79552468-79571942 bp, + strand Genetic Position: Chr10, 39.72 cM, cytoband C1
• Alliance: Hcn2^m2Btlr page

Mutation origin

• Strain of Origin: Not Specified
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced G to T transversion at base pair 79,733,773 (v38) on chromosome 10, or base pair 17,140 in the GenBank genomic region NC_000076 encoding Hcn2. The mutation corresponds to residue 1,641 in the mRNA sequence NM_178666 within exon 6 of 8 total exons. The mutation results in substitution of glutamic acid 536 for a premature stop codon (E536*) in the HCN2 protein. (J:267669)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hcn2 Mutation: 31 strains or lines available

References

• Original: J:267669 Mukherjee S, et al., Mutagenetix entry for curveball2. MGI Direct Data Submission. 2018
• All: 1 reference(s)