Npr3^kylb
Chemically induced Allele Detail

Summary

• Symbol: Npr3^kylb
• Name: natriuretic peptide receptor 3; kyphosis long body
• MGI ID: MGI:6269452
• Synonyms: KYLB
• Gene: Npr3 Location: Chr15:11839982-11907287 bp, - strand Genetic Position: Chr15, 5.83 cM
• Alliance: Npr3^kylb page

Mutation origin

• Strain of Origin: BALB/c

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU induced a T to A transversion at codon 209 resulting in a tyrosine to asparagine mutation. Experiments in cultured cells indicate that the mutant protein is retained in the endoplasmic reticulum. (J:243806)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Npr3 Mutation: 50 strains or lines available

References

• Original: J:243806 Esapa CT, et al., Mice with an N-Ethyl-N-Nitrosourea (ENU) Induced Tyr209Asn Mutation in Natriuretic Peptide Receptor 3 (NPR3) Provide a Model for Kyphosis Associated with Activation of the MAPK Signaling Pathway. PLoS One. 2016;11(12):e0167916
• All: 1 reference(s)