Tg(Camk2a-Polg*D181A)BTkato
Transgene Detail

Summary

• Symbol: Tg(Camk2a-Polg*D181A)BTkato
• Name: transgene insertion B, Tadafumi Kato
• MGI ID: MGI:6270168
• Transgene: Tg(Camk2a-Polg*D181A)BTkato Location: unknown
• Alliance: Tg(Camk2a-Polg*D181A)BTkato page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Camk2a-Polg*D181A)BTkato expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Polg (MGI:1196389)

• Mutation details: The mouse Polg cDNA in which an aspartate residue at position 181 was replaced with an alanine is under the control of the mouse calcium/calmodulin-activated protein kinase II alpha promoter. Three lines (A, B, and C) were generated. Line B is the high mRNA expressing line. RT-PCR confirmed expression of mRNA that is as abundant as the endogenous wild-type mRNA in most parts of the forebrain and mutant expression is nearly restricted in the brain. (J:127895)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:127895 Kasahara T, et al., Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes. Mol Psychiatry. 2006 Jun;11(6):577-93, 523
• All: 2 reference(s)