Il36a^tm1Yiw
Targeted Allele Detail

Summary

• Symbol: Il36a^tm1Yiw
• Name: interleukin 36A; targeted mutation 1, Yoichiro Iwakura
• MGI ID: MGI:6272256
• Synonyms: Il1f6^-
• Gene: Il36a Location: Chr2:24105429-24115713 bp, + strand Genetic Position: Chr2, 16.26 cM, cytoband A3
• Alliance: Il36a^tm1Yiw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263315
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2, 3 and 4 were replaced with an EGFP gene and a loxP-flanked neomycin selection cassette. qPCR analysis confirmed the absence of mRNA transcripts in the stomach and imiquimod (IMQ) cream-treated ears of homozygous mutant mice. (J:263315)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il36a Mutation: 12 strains or lines available

References

• Original: J:263315 Hashiguchi Y, et al., IL-36alpha from Skin-Resident Cells Plays an Important Role in the Pathogenesis of Imiquimod-Induced Psoriasiform Dermatitis by Forming a Local Autoamplification Loop. J Immunol. 2018 Jul 1;201(1):167-182
• All: 2 reference(s)