Bcl2a1a^tm1.1Tac
Targeted Allele Detail

Summary

• Symbol: Bcl2a1a^tm1.1Tac
• Name: B cell leukemia/lymphoma 2 related protein A1a; targeted mutation 1.1, Taconic
• MGI ID: MGI:6272374
• Gene: Bcl2a1a Location: Chr9:88838973-88844469 bp, + strand Genetic Position: Chr9, 47.24 cM
• Alliance: Bcl2a1a^tm1.1Tac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258915
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An approximately 7kb region, including both exons and the upstream promoter, was replaced with an F5 site, lox5171 site, neo cassette, attB/P site and an F5 site via homologous recombination. Flp mediated recombination removed the insert leaving a single F5 site. (J:258915)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl2a1a Mutation: 14 strains or lines available

References

• Original: J:258915 Schenk RL, et al., Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment. Cell Death Differ. 2017 Mar;24(3):534-545
• All: 5 reference(s)