Bcl2a1b^tm1.1Tac
Targeted Allele Detail

Summary

• Symbol: Bcl2a1b^tm1.1Tac
• Name: B cell leukemia/lymphoma 2 related protein A1b; targeted mutation 1.1, Taconic
• MGI ID: MGI:6272378
• Gene: Bcl2a1b Location: Chr9:89081326-89089891 bp, + strand Genetic Position: Chr9, 47.24 cM
• Alliance: Bcl2a1b^tm1.1Tac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258915
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the promoter region and an F3 site, attB/P site, HygR cassette, F3 site and loxP site were inserted downstream of exon 1. Flp mediated recombination removed the selection cassette leaving the gene floxed. Targeting was done in ES cells carrying Bcl2a1a^tm1Tac and Bcl2a1d^tm1Tac (J:258915)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl2a1b Mutation: 8 strains or lines available

References

• Original: J:258915 Schenk RL, et al., Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment. Cell Death Differ. 2017 Mar;24(3):534-545
• All: 3 reference(s)