Pgrmc1^em1Ejho
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pgrmc1^em1Ejho
• Name: progesterone receptor membrane component 1; endonuclease-mediated mutation 1, Eui-Ju Hong
• MGI ID: MGI:6272833
• Gene: Pgrmc1 Location: ChrX:35861859-35869732 bp, + strand Genetic Position: ChrX, 21.0 cM
• Alliance: Pgrmc1^em1Ejho page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: TALEN-mediated mutagenesis resulted in an 8 bp (CTGGGCCT) deletion in exon 1 which is predicted to result in a frameshift. Western blot analysis and immunohistochemistry confirmed absence of protein in the liver and uterus. (J:268130)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pgrmc1 Mutation: 11 strains or lines available

References

• Original: J:268130 Lee SR, et al., Loss of progesterone receptor membrane component 1 promotes hepatic steatosis via the induced de novo lipogenesis. Sci Rep. 2018 Oct 24;8(1):15711
• All: 4 reference(s)