Lrrk2^tm4.1Arte
Targeted Allele Detail

Summary

• Symbol: Lrrk2^tm4.1Arte
• Name: leucine-rich repeat kinase 2; targeted mutation 4.1, TaconicArtemis
• MGI ID: MGI:6273209
• Synonyms: G2019S-LRRK2
• Gene: Lrrk2 Location: Chr15:91557378-91700323 bp, + strand Genetic Position: Chr15, 46.07 cM, cytoband F1
• Alliance: Lrrk2^tm4.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:268603
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A proximal loxP site and FRT-flanked PGK-neomycin cassette were inserted in intron 41, a distal loxP site was inserted in intron 42, and G2019S mutation was inserted in exon 41 via homologous recombination. Flp mediated recombination removed the neo cassette. The expressed protein is resilient to kinase inhibition. (J:147112, J:268603)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrk2 Mutation: 159 strains or lines available

References

• Original: J:268603 Kelly K, et al., The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition. Exp Neurol. 2018 Nov;309:1-13
• All: 7 reference(s)