Lrrk2^tm2.1Dlbe
Targeted Allele Detail

Summary

• Symbol: Lrrk2^tm2.1Dlbe
• Name: leucine-rich repeat kinase 2; targeted mutation 2.1, Deanna L Benson
• MGI ID: MGI:6273308
• Synonyms: D2017A, DAKI
• Gene: Lrrk2 Location: Chr15:91557378-91700323 bp, + strand Genetic Position: Chr15, 46.07 cM, cytoband F1
• Alliance: Lrrk2^tm2.1Dlbe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234639
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 41 was replaced with one containing GAC to GCA nucleotide substitutions which results in an aspartate to alanine change at amino acid 2017 (D2017A). A loxP and frt-flanked PGK-neomycin cassette were inserted into intron 41 and another loxP site was inserted in intron 42. Flp-mediated recombination removed the neomycin cassette. This is a loss-of-kinase function mutation. (J:234639)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrk2 Mutation: 159 strains or lines available

References

• Original: J:234639 Matikainen-Ankney BA, et al., Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S Mutation. J Neurosci. 2016 Jul 6;36(27):7128-41
• All: 1 reference(s)