Irs1^em1(IMPC)H
Endonuclease-mediated Allele Detail

Summary

• Symbol: Irs1^em1(IMPC)H
• Name: insulin receptor substrate 1; endonuclease-mediated mutation 1, Harwell
• MGI ID: MGI:6273950
• Gene: Irs1 Location: Chr1:82210822-82269137 bp, - strand Genetic Position: Chr1, 42.0 cM, cytoband C5
• Alliance: Irs1^em1(IMPC)H page
• IMPC: Irs1 gene page

Mutation origin

• Strain of Origin: C57BL/6NTac
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele from IMPC was generated at Medical Research Council Harwell by injecting CAS9 RNA and 4 guide sequences TTACCGCCACCACTCTCAACAGG, TCAGGGGAGCAACTACCACTGGG, AGCCTCGCTATCCGCGGCAATGG, CCTCGCTATCCGCGGCAATGGCA, which resulted in a Intra-exdel deletion. (J:265051)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Irs1 Mutation: 52 strains or lines available

References

• Original: J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023
• All: 3 reference(s)