Tg(RP11-578M14)1Mkru
Transgene Detail

Summary

• Symbol: Tg(RP11-578M14)1Mkru
• Name: transgene insertion 1, M Katharine Rudd
• MGI ID: MGI:6273999
• Synonyms: deltaGNB3
• Transgene: Tg(RP11-578M14)1Mkru Location: unknown
• Alliance: Tg(RP11-578M14)1Mkru page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(RP11-578M14)1Mkru expresses 11 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD4 (920)

  Cd4	(MGI:88335)

  human

  CDCA3 (83461)

  Cdca3

  (MGI:1315198)

  human

  COPS7A (50813)

  Cops7a

  (MGI:1349400)

  human

  GPR162 (27239)

  Gpr162

  (MGI:1315214)

  human

  LAG3 (3902)

  Lag3	(MGI:106588)

  human

  MLF2 (8079)

  Mlf2	(MGI:1353554)

  human

  P3H3 (10536)

  P3h3	(MGI:1315208)

  human

  PTMS (5763)

  Ptms	(MGI:1916452)

  human

  SPSB2 (84727)

  Spsb2

  (MGI:1315199)

  human

  TPI1 (7167)

  Tpi1	(MGI:98797)

  human

  USP5 (8078)

  Usp5	(MGI:1347343)

• Mutation details: The transgene consists of a modified BAC RP11-578M14 (184 kb) in which a neomycin resistance cassette replaced the GNB3 gene. The modified BAC contains 13 human genes (MLF2, CD4, PTMS, LAG3, COPS7A, GPR162, P3H3 (LEPREL2), CDCA3, USP5, TPI1, SPSB2, RPL13P5, and DSTNP2) from 12p13.31. One line was generated. (J:201055)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:201055 Goldlust IS, et al., Mouse model implicates GNB3 duplication in a childhood obesity syndrome. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14990-4
• All: 1 reference(s)