Tlk2^tm1Strc
Targeted Allele Detail

Summary

• Symbol: Tlk2^tm1Strc
• Name: tousled-like kinase 2 (Arabidopsis); targeted mutation 1, Travis H Stracker
• MGI ID: MGI:6274360
• Synonyms: Tlk2^T
• Gene: Tlk2 Location: Chr11:105069633-105174785 bp, + strand Genetic Position: Chr11, 68.61 cM
• Alliance: Tlk2^tm1Strc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:268910
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutation: Insertion
• Mutation details: A construct, containing an FRT flanked cassette, encoding a splice-acceptor site, lacZ gene and neo resistance gene, and a loxP site, was inserted in intron 3 and a second loxP site was inserted in intron 4 via homologous recombination. Western blot analysis of lysates of MEFs from homozygous mice indicated the absence of protein expression. (J:268910)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlk2 Mutation: 71 strains or lines available

References

• Original: J:268910 Segura-Bayona S, et al., Differential requirements for Tousled-like kinases 1 and 2 in mammalian development. Cell Death Differ. 2017 Nov;24(11):1872-1885
• All: 1 reference(s)