Mir22^tm1Boet
Targeted Allele Detail

Summary

• Symbol: Mir22^tm1Boet
• Name: microRNA 22; targeted mutation 1, Thomas Boettger
• MGI ID: MGI:6274717
• Gene: Mir22 Location: Chr11:75354542-75354636 bp, + strand Genetic Position: Chr11, 45.91 cM
• Alliance: Mir22^tm1Boet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266382
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• An IRES-lacZ-neomycin cassette replaced the microRNA sequence. (J:266382)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir22 Mutation: 6 strains or lines available

References

• Original: J:266382 Schweisgut J, et al., Sex-specific, reciprocal regulation of ERalpha and miR-22 controls muscle lipid metabolism in male mice. EMBO J. 2017 May 2;36(9):1199-1214
• All: 1 reference(s)