Nf1tm1d(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Nf1tm1d(KOMP)Wtsi |
Name: |
neurofibromin 1; targeted mutation 1d, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:6275187 |
Synonyms: |
Nf1delta4 |
Gene: |
Nf1 Location: Chr11:79230519-79472438 bp, + strand Genetic Position: Chr11, 46.74 cM, cytoband B4-5
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Alliance: |
Nf1tm1d(KOMP)Wtsi page
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IMPC: |
Nf1 gene page |
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Mutant Cell Line: |
EPD0033_1_F12 |
Germline Transmission: |
Earliest citation of germline transmission:
J:234172
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Parent Cell Line: |
JM8.F6 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
Vector: L1L2_gt0
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Mutation details: The L1L2_gt0 cassette was inserted at position 79280528 of Chromosome 11 upstream of the critical exon 4 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon at position 79281558. The critical exon 4 is thus flanked by loxP sites. A "conditional ready" (floxed) allele is created by flp recombinase expression in mice carrying this allele. The knockout allele was created by deletion exon 4 through subsequent cre-mediated recombination.
(J:234172)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Nf1 Mutation: |
161 strains or lines available
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Original: |
J:234172 Li K, et al., Mice with missense and nonsense NF1 mutations display divergent phenotypes compared with human neurofibromatosis type I. Dis Model Mech. 2016 Jul 1;9(7):759-67 |
All: |
1 reference(s) |
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