About   Help   FAQ
Nf1tm1d(KOMP)Wtsi
Targeted Allele Detail
Summary
Symbol: Nf1tm1d(KOMP)Wtsi
Name: neurofibromin 1; targeted mutation 1d, Wellcome Trust Sanger Institute
MGI ID: MGI:6275187
Synonyms: Nf1delta4
Gene: Nf1  Location: Chr11:79230519-79472438 bp, + strand  Genetic Position: Chr11, 46.74 cM, cytoband B4-5
Alliance: Nf1tm1d(KOMP)Wtsi page
IMPC: Nf1 gene page
Mutation
origin
Mutant Cell Line:  EPD0033_1_F12
Germline Transmission:  Earliest citation of germline transmission: J:234172
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion     Vector: L1L2_gt0
 
Mutation detailsThe L1L2_gt0 cassette was inserted at position 79280528 of Chromosome 11 upstream of the critical exon 4 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon at position 79281558. The critical exon 4 is thus flanked by loxP sites. A "conditional ready" (floxed) allele is created by flp recombinase expression in mice carrying this allele. The knockout allele was created by deletion exon 4 through subsequent cre-mediated recombination. (J:234172)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nf1 Mutation:  161 strains or lines available
References
Original:  J:234172 Li K, et al., Mice with missense and nonsense NF1 mutations display divergent phenotypes compared with human neurofibromatosis type I. Dis Model Mech. 2016 Jul 1;9(7):759-67
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory