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Nf1tm1d(KOMP)Wtsi
Targeted Allele Detail
Summary
Symbol: Nf1tm1d(KOMP)Wtsi
Name: neurofibromin 1; targeted mutation 1d, Wellcome Trust Sanger Institute
MGI ID: MGI:6275187
Synonyms: Nf1delta4
Gene: Nf1  Location: Chr11:79230519-79472438 bp, + strand  Genetic Position: Chr11, 46.74 cM, cytoband B4-5
Alliance: Nf1tm1d(KOMP)Wtsi page
IMPC: Nf1 gene page
Mutation
origin
Mutant Cell Line:  EPD0033_1_F12
Germline Transmission:  Earliest citation of germline transmission: J:234172
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion     Vector: L1L2_gt0
 
Mutation detailsThe L1L2_gt0 cassette was inserted at position 79280528 of Chromosome 11 upstream of the critical exon 4 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon at position 79281558. The critical exon 4 is thus flanked by loxP sites. A "conditional ready" (floxed) allele is created by flp recombinase expression in mice carrying this allele. The knockout allele was created by deletion exon 4 through subsequent cre-mediated recombination. (J:234172)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nf1 Mutation:  161 strains or lines available
References
Original:  J:234172 Li K, et al., Mice with missense and nonsense NF1 mutations display divergent phenotypes compared with human neurofibromatosis type I. Dis Model Mech. 2016 Jul 1;9(7):759-67
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory