Gt(ROSA)26Sor^{tm2(CAG-Nr5a1)Fjd}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(CAG-Nr5a1)Fjd}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Franco J DeMayo
• MGI ID: MGI:6275547
• Synonyms: SF1^LSL
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(CAG-Nr5a1)Fjd} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269597
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2(CAG-Nr5a1)Fjd} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Nr5a1 (MGI:1346833)

• Mutation details: The targeting construct inserted into the locus a CAGGS promoter (consisting of the chicken beta-actin promoter and the cytomegalovirus enhancer), a loxP-STOP-loxP cassette, a cDNA encoding a tandem FLAG-Myc-tagged mouse Nr5a1 gene, and a polyadenylation signal. This creates a conditional-ready allele where the inserted gene is only expressed after the removal of the STOP cassette through cre-mediated recombination. (J:269597)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:269597 Vasquez YM, et al., Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis. Mol Endocrinol. 2016 May;30(5):518-32
• All: 2 reference(s)