Tg(Myh6-Camk2d_ic)MJhb
Transgene Detail

Summary

• Symbol: Tg(Myh6-Camk2d_ic)MJhb
• Name: transgene insertion M, Joan Heller Brown
• MGI ID: MGI:6276040
• Synonyms: TGM
• Transgene: Tg(Myh6-Camk2d_ic)MJhb Location: unknown
• Alliance: Tg(Myh6-Camk2d_ic)MJhb page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Camk2d_ic)MJhb expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Camk2d (24246)

  Camk2d

  (MGI:1341265)

  cytoplasmic isoform

• Mutation details: A hemagglutinin (HA)-tagged rat cDNA for the cytoplasmic variant of Camk2d is under the control of the 5.5-kb murine alpha-MHC promoter. Immunocytochemical staining confirmed that the expressed transgene is expressed only in the heart and is confined in the cytoplasm of cardiomyocytes. Three lines (TGL, TGM, and TGH) were generated. This TGM line carries 5 copies of the transgene and is the medium copy number line. Protein levels are increased 17-fold over wild-type levels but the amount of activated Camk2d is only increased 3-fold in hearts. (J:130644)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1  Disease Model	Tg(Myh6-Camk2d_ic)MJhb/0	either: (involves: Black Swiss) or (involves: C57BL/6)

Phenotypes:

Affected Systems	tg1
show or hide all annotated terms
cardiovascular system	√
pulmonary vascular congestion	√
increased myocardial fiber size	√
dilated heart atrium	√
enlarged heart	√
cardiac hypertrophy	√
dilated heart ventricle	√
cardiac fibrosis	√
dilated cardiomyopathy	√
decreased cardiac muscle contractility	√
abnormal heart echocardiography feature	√
abnormal myocardial fiber physiology	√
congestive heart failure	√
growth/size/body	√
enlarged heart	√
cardiac hypertrophy	√
homeostasis/metabolism	√
abnormal atrial thrombosis	√
edema	√
pleural effusion	√
mortality/aging	√
premature death	√
muscle	√
increased myocardial fiber size	√
dilated cardiomyopathy	√
decreased cardiac muscle contractility	√
respiratory system	√
pulmonary vascular congestion	√
pleural effusion	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	tg1
congestive heart failure IDs congestive heart failure       DOID:6000 DOID:395 ICD10CM:I50 ICD10CM:I50.9 ICD9CM:428 ICD9CM:428.0 ICD9CM:428.9 MESH:D006333 NCI:C3080 NCI:C50577 UMLS_CUI:C0018801 UMLS_CUI:C0018802 Close	√
dilated cardiomyopathy IDs dilated cardiomyopathy       DOID:12930 EFO:0000407 ICD10CM:I42.0 KEGG:05414 MESH:D002311 NCI:C84673 OMIM:PS115200 ORDO:217604 UMLS_CUI:C0007193 Close	√

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:130644 Zhang T, et al., The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res. 2003 May 2;92(8):912-9
• All: 3 reference(s)