Kif6^em1Rgray
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kif6^em1Rgray
• Name: kinesin family member 6; endonuclease-mediated mutation 1, Ryan Gray
• MGI ID: MGI:6276219
• Synonyms: Kif6^p.G555fs
• Gene: Kif6 Location: Chr17:49922164-50216875 bp, + strand Genetic Position: Chr17, 25.78 cM, cytoband C
• Alliance: Kif6^em1Rgray page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 mutagenesis was used to generate a site in exon 14 (c.1665ins) to insert a 3-stop donor cassette, providing integration of an ochre termination codon in all three reading frames into the endogenous gene. This mutation introduced a truncation in the protein reading frame at codon 555. (J:269442)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kif6 Mutation: 36 strains or lines available

References

• Original: J:269442 Konjikusic MJ, et al., Mutations in Kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development. PLoS Genet. 2018 Nov;14(11):e1007817
• All: 1 reference(s)